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Shingu M, and Nobunaga M (1984)

vivax invades red blood cells via its merozoite form, which replicates within the host

While most therapies aim to downregulate neutrophils to prevent protease damage, inhaled GM-CSF aims to restore or enhance neutrophil bactericidal function, which may be beneficial for clearing persistent infections like NTM A phase 1 randomized, double-blind, placebo-controlled clinical trial (NCT02468908) involving healthy adults has been completed in the UK

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Granulocyte-macrophage colony stimulating factor (GM-CSF) is found at increased concentrations in the BAL fluid of patients with stable COPD and at markedly elevated levels during exacerbations 13

While proteasomal dysfunction is correlated with age progression and protein aggregation, proteasome activation slows the aging progress down and increases longevity (Chondrogianni et al., 2014)