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The Molecular Pathology of Melanoma: An Integrated Taxonomy of Melanocytic Neoplasia

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Although the term PEM allows one to deal with diagnostically challenging pigmented melanocytic tumors, for which a reliable distinction between melanoma and an unusual pigmented nevus is difficult or impossible by light microscopic examination alone, we caution against labeling lesions as PEM, which previously would have been diagnosed as benign EBN or pigmented dermal spindle and epithelioid cell nevus

additional controlled studies are warranted to define safety, dosing, and efficacy parameters in new contexts.

Adjuvant interferon2B therapy has already been approved for the treatment of primary cutaneous melanomas more than 4 mm in thickness