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BH4 and HDFA did not demonstrate effects on cysteine metabolism

A 2012 study in *Nutritional Neuroscience* suggested oral glutathione may improve irritability and hyperactivity in some children, but sample sizes were limited and placebo controls were absent in many studies

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The observation that restoration of the redox environment recovers ATP production and Complex I activity indicates the possibility that pharmacological agents can be designed and targeted to mitochondria to ameliorate deregulated S-glutathionylation reactions