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Concurrently, reduced glutamine levels reflect increased consumption by activated immune cells, which exacerbates inflammatory responses and further represses ABCB11 and ABCB4 expression 41

doi: 10.1016/j.ijpharm.2019.118782 125 LiuXZhuXQiXMengXXuK

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The similarity of Acs binding sites for isoxazole 1 and MMV089478 is further supported by the fact that mutations in the CoA/isoxazole 1 binding region of Ca Acs2 enzyme designed to match those found in Cn Acs1 led to a Ca Cn Acs2 mutant enzyme that was inhibited by both compounds when the WT Ca Acs2 was not

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Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men