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The double mutant pcs1pcs2 impaired in phytochelatin synthesis and the catabolism of glutathione conjugates 61,62 showed also a WT-like phenotype when exposed to AITC

20 As the rapid rise in atmospheric O 2 presented a new challenge for cellular energetics, single-celled life forms were forced to adapt, including giving rise to multicellular life

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Recent studies have demonstrated that the depletion of GSH can be obtained acting on the different steps of the GSH cycle, triggering mechanisms able to stimulate, as a final result, cancer cell death

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