Semaglutide has also shown potential in being used as a therapeutic strategy in Alzheimers disease due to its anti-neuroinflammatory effects and being used to treat polycystic ovary syndrome
Methods: Patients with depression and low normal B12 levels were randomized to a control arm (antidepressant only) or treatment arm (antidepressants and injectable vitamin B12 supplementation)
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Chaimani A, Higgins JP, Mavridis D, et al
Options for managing tolerance include a brief dose reduction for 4 to 8 weeks ("drug holiday" at a lower dose, not complete cessation), lifestyle optimization to maximize the medication effect, evaluation for other contributing factors (thyroid function, cortisol, sleep quality, medication interactions), and consideration of adding a complementary compound to address specific aspects of the plateau
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