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Abbreviations -SMA Alpha-Smooth Muscle Actin ACC Acetyl-CoA Carboxylase AFLD Alcoholic Fatty Liver Disease ALD Alcohol-Associated Liver Disease ALI Acute Lung Injury ALT Alanine Aminotransferase AMPK Adenosine Monophosphate-Activated Protein Kinase AREs Antioxidant Responsive Elements ASH Alcoholic Steatohepatitis AST Aspartate Aminotransferase CCL4 Carbon Tetrachloride 4 CD Cluster of Differentiation ChoRE Carbohydrate Response Element ChREBP Carbohydrate Response Element Binding Protein CO Carbon Monoxide CPT1 Carnitine Palmitoyltransferase 1 DAMPs Damage-Associated Molecular Patterns DNL De Novo Lipogenesis ECM Extracellular Matrix ERS Endoplasmic Reticulum Stress FAO Fatty Acid Oxidation FASN Fatty Acid Synthase FFA Free Fatty Acid G6PD Glucose-6-Phosphate Dehydrogenase GRP78 Glucose-Regulated Protein 78 GSH Glutathione HCC Hepatocellular Cancer HFD High-Fat Diet HO-1 Heme Oxygenase-1 HSC Hepatic Stellate Cell IL-6 Interleukin-6 IB Inhibitor of B JAZF1 Juxtaposed with Another Zinc Finger Protein 1 Keap1 Kelch-Like ECH-Associated Protein 1 LKB1 Liver Kinase B1 LPS Lipopolysaccharide M1 Macrophage 1 MASH Metabolic dysfunction-Associated Steatohepatitis MASLD Metabolic dysfunction-Associated Steatotic Liver Disease MFN2 Mitofusin 2 NA Nicotinic acid NAD + Nicotinamide Adenine Dinucleotide NADH Nicotinamide Adenine Dinucleotide (reduced form) NAM Nicotinamide NAMN Nicotinic Acid Mononucleotide NAMPT Nicotinamide Phosphoribosyltransferase NASH Non-Alcoholic Steatohepatitis NF-B Nuclear Factor-B NMN Nicotinamide Mononucleotide NMNAT Nicotinamide Mononucleotide Adenylyltransferase NMNH Nicotinamide Mononucleotide Hydrogen NNMT Nicotinamide N-Methyltransferase NO Nitric Oxide NR Nicotinamide Riboside NRF2 Nuclear Factor Erythroid 2-Related Factor 2 NRH Dihydronicotinamide Riboside NSDP Nisoldipine Derivative PARP1 Poly (ADP-Ribose) Polymerase 1 PGC-1 Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha PPAR Peroxisome Proliferator-Activated Receptor Alpha QAPRT Quinolinic Acid Phosphoribosyltransferase RAGE Receptor for Advanced Glycation End Products ROS Reactive Oxygen Species SARM1 Sterile Alpha and TIR Motif Containing 1 SOD Superoxide Dismutase SREBP-1c Sterol Regulatory Element Binding Protein-1c TCA Tricarboxylic Acid TG Triglycerides TLR4 Toll-Like Receptor 4 TNF- Tumor Necrosis Factor-Alpha UPR Unfolded Protein Response Author contributions YXG and YTW performed literature investigation and wrote the manuscript

A deficiency in Vitamin B12 leads to inefficient use of energy, making it more difficult to do physical activities for weight loss

Scheduling too aggressively risks vitamin toxicity, fluid overload, and vein damage

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Shi P, Gal J, et al

2020 Jul 24;21(15):5262