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2.3 The relationship between ferroptosis and other programmed cell death responses Ferroptosis is intricately linked to biological processes, including autophagy, endoplasmic reticulum stress, and inflammation, among others, and may be involved in the reciprocal regulation of recalcitrant diseases

In fact, it was demonstrated that Erastin can potentially activate VDAC channel [50], which results in mitochondrial disruption [51] and lead to apoptotic cell death in gastric [52] and colorectal cancer cells [34]

10.3389/fphar.2021.739615 21 ChenX.WeiW.LiY.HuangJ.CiX

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Therefore, we previously suggested that GSH efflux is necessary to some extent, but not sufficient, for the selective death induction of MRP1-expressing cells 18