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523 Analysis of gene expression in cortical astrocytes from old mice identified an increase in genes linked to an immune response with a decrease in expression of GFAP and genes related to neuroprotection and neuronal support, 524 and the prominent up-regulation of genes contributing to synapse elimination in astrocytes from aged hippocampus and cerebellum

That is why certain life stages are associated with symptoms of decreased mental clarity and less emotional stability

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Patients with prior nasal surgery may be at increased risk for vascular compromise due to altered blood supply and scarring to the area

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Therefore, reducing the dose or discontinuing the supplement may alleviate these symptoms