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In these participants, concentrations of latent myostatin, a pharmacodynamic marker, increased substantially after the first dose, achieved a plateau at approximately week 16 and remained consistently elevated throughout the treatment period, demonstrating successful target engagement (Extended Data Fig

DOI: 10.1530/eje.0.1390552 Ankersen M, Johansen NL, Madsen K, Hansen BS, Raun K, Nielsen KK, et al

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After 6 weeks, it reaches 97%

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