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In this study, we confirmed that Nedd4-2 binds to the membrane in a Ca 2+ -dependent manner through liposome-binding assays using large unilamellar vesicles (LUVs) prepared from porcine brain polar lipid extract (BE) to mimic the physiological lipid composition of brain cells (Fig

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System Xc is a heterodimeric amino acid transport complex consisting of a heavy-chain 4F2hc protein (i.e., recombinant solute carrier family 3 member 2, SLC3A2) and a light-chain xCT protein (recombinant solute carrier family 7 member 11, SLC7A11) (Sato et al