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Interestingly, MGMT is a DNA repair enzyme responsible for demethylating O6-methylguanine in normal cells, which repairs the O6-alkylguanine lesions in DNA by transferring the alkyl groups from the O6-position of guanine to its own active center Cys145 residue and restores normal DNA

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The primary outcome will be the central macular subfield thickness (CSMT) on optical coherence tomography imaging at 24 months