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High homocysteine levels are also associated with osteoporosis as it reduces bone blood flow and causes bones to become more fragile, per a 2017 study in the Journal of Cellular Physiology

El Khoudary SR, Greendale G, Crawford SL, et al

(2021) and Frank et al

An integrated portable system for single chip simultaneous measurement of multiple disease associated metabolites

Koch T, Seifert A, Wu DF, Rankovic M, Kraus J, Borner C et al (2009) Mu-opioid receptor-stimulated synthesis of reactive oxygen species is mediated via phospholipase D2