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Signal : (noun) From Old French signe and Old Latin signum as in a sign or token, morphing to medieval Latin signale and Old French signal or seignal meaning a sign or mark, and more modern Latin signalis

But the approval of the prime minister was needed

Archived from the original on 26 January 2018

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in the race to develop an acceptable, non-combustible device for nicotine delivery, Philip Morris was as worried about competition from the pharmaceutical industry as its rivals in the tobacco sector In May 1992, an internal Philip Morris document, Products of the Future, stated the reason for this experimentation, noting Premier probably changed the cigarette business forever.[22] It is interesting that in the race to develop an acceptable, non-combustible device for nicotine delivery, this document reveals Philip Morris was as worried about competition from the pharmaceutical industry as its rivals in the tobacco sector

Nornicotine is self-administered intravenously by rats