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Therefore, hepatocytes in the centrilobular area produce more NAPQI and deplete GSH faster than cells in the periportal area 25,26

Ramachandran V, Watts LT, Maffi SK, Chen J, Schenker S, Henderson G

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The resulting consensus provides an integrated synthesis of available evidence, incorporating data from RCTs, systematic reviews, meta-analyses, in vitro , and animal studies