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In addition to the above, some natural medicines have been proved to have anti-RA activity ( Table 1 ): polyphenols including curcumin, chlorogenic acid and punicalagen, flavonoids including hesperidin, 7,3-dimethoxyhesperidin, kaempferol and genistein, terpenes including pentaacetyl geniposide, gentiopicrin and betulinic acid, glycosides including emodin, and cyanidin-3-O-glucuronide, alkaloids including berberine and matrine, -mangiferin (a xanthone derivative of mangosteen pericarp), cinnamaldehyde (an aldehyde active compound Chinese medicine herb Cinnamomum cassia), thymoquinone (the main component of the volatile oil in Nigella sativa L.), periplocin (one of the main active components in Periploca sepium Bunge)

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A placebo-controlled trial in 15 patients undergoing iridotomy to prevent closed-angle glaucoma found taking 300 mg oral PEA twice daily for 15 days prior to the procedure resulted in no significant increase in IOP following surgery