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Indeed, a non-resolved stroke is associated with persistent secondary inflammation, with profound impacts on pre-existing neurological conditions or subsequent brain injury

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It leads to an increase in blood supply with the consequent BP reduction ( 2 , catalyzed by NO synthase (NOS), which consists of three isoforms: endothelial (eNOS), inducible (iNOS), and neuronal (nNOS)

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Therefore, the potential mechanisms of oxidative response help to find the novel and more effective therapies for CS-induced emphysema