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Changes in intracellular signaling for the fibroblast to move are also required, and this is necessitated by downstream signaling mediated by sonic hedgehog, WNT/-catenin, ROCK/Rho, and PI3K/AKT

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Anesth Analg 89:12091215 Abdel-Zaher AO, Mostafa MG, Farghaly HS, Hamdy MM, Abdel-Hady RH (2013) Role of oxidative stress and inducible nitric oxide synthase in morphine-induced tolerance and dependence in mice