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doi: 10.1074/jbc.M112.390369

(Its not clear if the peptides were responsible for the symptoms.) Considering the skin-darkening peptide melanotan II (sometimes called the Barbie peptide)

When two peptides compete for the same receptor, they do not produce additive effects

Here is a clear-eyed overview of where the evidence stands across the three peptides most relevant to PMOS

Human clinical trial data for IGF-1 DES is essentially nonexistent - no Phase II or III trials have been conducted, making it difficult to establish safety, optimal dosing, or clinical efficacy for any medical condition