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Afterward, before counterstaining with hematoxylin the specimens and cells were visualized until brown color with DAB kit (Thermo Scientific, USA) at dark condition

This ferroptosis-enhanced macrophage regulation strategy may apply to other iron-based nanomaterials and iron-related lethal agent combinations

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Intravenous therapy, or IV therapy, introduces the molecule directly into the bloodstream and ensures complete and immediate absorption, with generally faster effects

Prideaux M, Kitase Y, Kimble M, O'Connell TM, Bonewald LF

Molecular pathways documented in preclinical research include: (1) activation of nitric oxide (NO) synthesis via L-arginine/eNOS pathway, (2) transcriptional upregulation of VEGF-A and FGF-2 favouring angiogenesis, (3) modulation of the Egr-1 early transcription factor involved in fibroblast proliferation, (4) interaction with 5-HT2A and dopaminergic receptors in some behavioural models, (5) stabilisation of endothelial function via eNOS modulation and reduction of oxidative stress (8-OH-dG, MDA)