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Description

Other suitable substitutions within the MMP-29 catalytic domain are encompassed by the present invention and are referenced elsewhere herein

Elevated 27HC levels in hepatocellular carcinoma cells upregulate glutathione peroxidase 4 (GPX4), leading to ferroptosis resistance and promoting cancer proliferation ( Transforming growth factor 1 (TGF-1) secreted by cancer-associated fibroblasts (CAFs) activates JUN signaling in hepatocellular carcinoma cells, leading to increased semaphorin-3C (SEMA3C) expression