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Precisely, superoxide anion and hydrogen peroxide have been reported to act as mitogens, thereby promoting the rate of DNA replication and cell proliferation in a variety of cultured cells.9, 10 Nonetheless, in excess amounts, oxygen-derived radicals are very harmful to living organisms

While our study employs a small-molecule-based strategy targeting cysteine metabolism via dual GGCT/xCT inhibition, the concept of GSH depletion-mediated ferroptosis is mechanistically aligned with these approaches

A Separate study have shown that 2 M arsenic trioxide can induce apoptosis in U87MG, U251, SHG44 and C6 glioma cells in a dose-dependent manner [30]

Excessive caffeine consumption may interfere with iron absorption and stress the adrenal glands, potentially accelerating hair loss in susceptible individuals

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D-mannose alleviates osteoarthritis progression by inhibiting chondrocyte ferroptosis in a hif-2-dependent manner