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Despite mostly promising preclinical data, meta-analyses of clinical trials indicate that oxytocin treatment does not significantly improve impaired social and repetitive behaviors in adults with ASD [110], with only a moderate effect observed in children [111]

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7.2 The mechanism and molecular target of taurine The main mechanism for the absorption of taurine in tissues is through the chloride sodium taurine transporter, and it has been found that Gamma-aminobutyric acid (GABA) transporter 2 at BBB is capable of transporting hypotaurine and taurine (127)

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Its mechanism of action involves primarily modulating afferent pathways of the vagus nerve, thereby influencing neural circuits in the cerebral cortex and limbic system to promote neuroplasticity and stabilize neural networks (4042)

Finally, using ABA, the concentration of 1.0 mg L 1 resulted in the highest maturation frequency among all treatments evaluated ( p 0.05) (Table 4, Fig