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Statistical analysis was performed using a Welchs t -test ( b, c and e, f ) or two-sided Gehan-Breslow-Wilcoxon test comparing the altered and unaltered groups for each chromosome arm ( d )

Alveolar differentiation drives resistance to KRAS inhibition in lung adenocarcinoma

The resulting glutamine surplus aggravates glutamine-induced osmotic stress in the cytoplasm, rendering more glutamine available for: (i) its system y + L (Slc7a6)-mediated exchange for extracellular arginine (Arg), which increases the intra-astrocytic accumulation of reactive oxygen-nitrogen species (ROS), (ii) glutamine enter to astrocytic mitochondria, where, hydrolyzed to glutamate and NH 4 + by PAG leads to open mitochondrial permeability transition pore (mPTP), and mitochondrial dysfunction (the Trojan Horse mode of action)

Legry, V

Advances in Clinical Chemistry, Volume 85, 2018, Pages 31-69 Effects of L-Carnitine Supplementation on Metabolic Utilization of Oxygen and Lipid Profile among Trained and Untrained Humans

Effective treatment targets hypoxia/reoxygenation injury and aims to reduce inflammation and oxidative stress (Geng et al., 2020