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21 The top 10% of proteins within these networks were scored for network topology (connectivity and bottleneck) and used as markers of essential pathway functions, 22, 23 which were identified using the Reactome algorithm 24 plug-in for Cytoscape 2.8.2 25 (Supplementary Figure S2)

The primary hurdle, as discussed, has been its inherently poor bioavailability, which makes achieving therapeutically relevant concentrations in human tissues challenging with conventional oral dosing

We thank and acknowledge the Indian Council of Medical Research (ICMR) for providing the Senior Research Fellowship to Aakash Kumar S

Such carbohydrate modifications can be accomplished by, for example, altering one or more sites of glycosylation within the antibody sequence

Because experimental studies suggest it interacts with multiple biological signalling pathways involved in tissue biology and cellular communication

This glutamate uptake in astrocytes requires the energy generated by the entry of Na + ions into the astrocytes through the cis-electrochemical gradient