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The researchers sought to determine if oxidative stress was actively driving the peripheral vasoconstriction and blood pooling characteristic of the condition

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Oral Cit supplementation increases NO synthesis by elevating plasma Arg concentration [122], and if Arg availability is limited, Cit supplementation can restore NO production [71]

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Abbasnezhad A, Amani R, Hajiani E, Alavinejad P, Cheraghian B, Ghadiri A

The mechanisms and roles of melatonin in gastrointestinal cancer