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Downstream of mitochondrial damage, lactate-driven histone H4K12 lactylation activates the NF-B signalling pathway, triggering excessive oxidative stress and inflammation-fibrosis coupling

Ginsenoside Rg1, a major active component isolated from Panax notoginseng, restrains tubular epithelial to myofibroblast transition in vitro

For example, in patients with congestive heart failure, reduced cardiac output leads to decreased Q H and therefore decreased clearance, resulting in higher plasma concentrations and an increased risk of toxicity

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We then treated the reactivated Raji cells with several concentrations of TNF- (10, 100, 200, 300, 400, and 500 ng/ml)

Baker DJ, Childs BG, Durik M, et al