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Reduced levels of vitamin K result in less blood clotting, a phenomenon sometimes referred to as blood thinning

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Many small-molecule synthetic antioxidants (such as vitamin C and N-acetylcysteine) have shown limited effectiveness in clinical trials for sepsis, primarily because they neutralize ROS at a 1:1 stoichiometric ratio and become ineffective once depleted

This is why B12 is often linked to cognitive function, memory, and even mood regulation

These findings suggest that suppressing ammonia accumulation in immune cells or targeting ammonia-induced cell death pathways may represent a promising strategy to prolong Teff survival and optimize CAR-T therapy