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Edaravone: a novel possible drug for cancer treatment

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The major pathways that regulate ferroptosis include glutathione peroxidase 4 (GPX4)-glutathione (GSH), ferroptosis-suppressor-protein 1 (FSP1)-CoQ 10 , FSP1-vitamin K (VK), dihydroorotate dehydrogenase (DHODH)-CoQ, and GTP cyclohydrolase 1 (GCH1)-tetrahydrobiopterin (BH 4 )

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The CV tests were performed in an O 2 -saturated NaAc solution (0.1 M, pH 4.0) with TMB (1 mM)

Collectively, these findings demonstrate that Hcy promotes endothelial senescence through the MARS1-HTL-K-Hcy pathway, with elevated MARS1 and HTL levels in mid-old conditions further amplifying the overall signaling cascade