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Abstract 3,4-Methylenedioxymethamphetamine (MDMA), widely misused for its euphoric and stimulant properties, induces overt neurotoxicity in rodents and non-human primates and is associated with profound neurochemical and structural brain alterations

doi: 10.1007/s00018-006-6256-7 51 StollSWZhaoXElderJT

NathanJKhedekar KaleDNaikVDThakkerFBailurS

compositions as described herein may be reconstituted in, or may comprise, a liquid carrier (for example, water or juice), allowing for straightforward oral administration

CH was supported by the MRC Human Genetics Unit quinquennial programme grant QTL in Health and Disease (MC_UU_00007/10)

In a 3D culture format using human biopsy-derived ileal organoids and colonoids, differentiated organoids showed PXR-mediated induction of CYP3A4 expression, a response that is largely absent in parental Caco-2 cells 58