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Bladder cancer has become the most common malignancy of the urinary system, and there is currently no effective treatment strategy for invasive bladder cancer

In recent years, the incidence rates of AITD and thyroid cancer Have risen significantly, reaching approximately 5% and 20%, respectively (Antonelli et al

The biomarker deficit fundamentally constrains clinical trial design by preventing patient stratification based on mitochondrial dysfunction severity and precluding early detection of therapeutic response or toxicity

In normal cells, rhamnetin activates Nrf2, boosting antioxidant defenses, reducing basal ROS levels, and protecting cellular structures from oxidative damage

Glutathione peroxidase masterfully regulates this balance, scavenging surplus ROS to prevent cellular chaos

( c ) UMAP of the integrated multispecies atlas, individually colored by specieshuman (blue), mouse (orange), and rat (green)