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High-dose riboflavin has shown efficacy in stabilizing mutant AIFM1 and improving clinical features in some patients, marking it as a prototypical FAD-sensitive genotype

2006 Jan;141(1):201-3

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coli Rosetta2 (DE3) cells (Novagen) transformed with the above plasmids were cultured as previously reported (Schenck et al., 2017)

Although normal electron transport in mitochondria involves four-electron reduction of O 2 to water, partial reduction reactions occur under physiological conditions, causing release of superoxide anion and hydrogen peroxide (H 2 O 2 )