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Atherosclerosis (hardening of the arteries) It is possible that steroids may increase the rate of "hardening of the arteries," which could increase the risk of heart disease

PMID: 8821391

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Conversely, at pH values above the said isoelectric point but not significantly higher, the degree of primary dissociation of phosphate groups exceeds the degree of protonation of bases, leading to a net negative charge on nucleotide molecules