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Krecek, R.C., Lee, E., Lucas, H., Drebot, M.A., Wood, H., Loftis, A., Robertson, L., Dimitrova, K., Makowski, K., Dillon, L., Dewailly, E., Morrison, K., Forde, M., Kelly, P., (2013)

Enhanced cancer therapy by hypoxia-responsive copper metal-organic frameworks nanosystem

In conclusion, although many reports previously evidenced the regulation of signaling pathways by GSTs in various in vitro cell systems, we demonstrate for the first time that the invalidation of Gstp1/p2 affects multiple key events of the hepatocyte cell cycle in vivo after PH

Conversely, at high concentrations, it can oxidize the cysteine (SH) or methionine residues (SCH 3 ), which subsequently leads to the inactivation of enzymes like Calvin cycle, Cu/Zn-SOD, and Fe-SOD by oxidation of their thiol groups [48]

Adv Pharmacol 85:263272 Hanawa N, Shinohara M, Saberi B, Gaarde WA, Han D, Kaplowitz N (2008) Role of JNK translocation to mitochondria leading to inhibition of mitochondria bioenergetics in acetaminophen-induced liver injury