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Interestingly, although mice exhibiting delirium-like behavior after general anesthesia and surgical laparotomy showed distinct gut microbiota dysbiosis, transplanting gut microbiota from mice without delirium to those exhibiting delirium-like behaviors improved cognitive symptoms (Zhang et al., 2019)

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5-Amino-1MQ functions as a small-molecule inhibitor of NNMT, the enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide

287 In a model of colitis induced by dextran sulfate sodium (DSS), it was demonstrated that vitamin D receptor (VDR)-knockout mice showed more severe diarrhea and ulceration than a control group

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