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The most severe of these are listed below

However, the vast heterogeneity of the pathogenic mechanisms underlying these conditions, along with the difficulty of diagnosis and the assumption that diets from developed countries supply enough thiamine to match the caloric intake (including perinatal periods), has not prompted enough research to address the role and effects of thiamine supplementation as a therapeutic strategy in the context of neurodevelopment/neurodegeneration

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This results in temporary muscle paralysis, which in turn relaxes and smooths the overlying skin

Shisa6 traps AMPA receptors at postsynaptic sites and prevents their desensitization during synaptic activity