glutathione variegate porphyria A 9‐year‐old girl with blisters on the hands and face: An early presentation of - Moshayedi - 2023 - Pediatric Dermatology Variegate Porphyria – Biochemistry @

Synergy Hypothesis (No PK Interaction) : The most accepted hypothesis suggests they do not interfere with each others PK (absorption, metabolism, half-life)

One theory is that low BH4 levels due to oxidative stress may shift tryptophan metabolism away from serotonin and toward the kynurenine pathway.[ref] BH4 is also essential for the neurotransmitters norepinephrine and epinephrine since they are made from dopamine

Current understanding of hypothalamic amenorrhoea

10.1016/j.micpath.2021.105269 14 ChristensonS

doi: 10.3724/abbs.2022093

While Hinge alone did alter base-line synaptic transmission it attenuated HGF and Dihexa increases in AMPA-frequencies (FIGS