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Selenocysteine A selenium analogue of cysteine, where selenium replaces sulfur

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Yang F, Wu Y, Hockey R, Doust J, Mishra GD, Montgomery GW, et al

Although strategies such as iron chelators (e.g., deferoxamine), antioxidants (e.g., N-acetylcysteine), and GPX4 activation demonstrate neuroprotective potential in animal and cellular models, their safety, tolerability, blood-brain barrier permeability, and ability to modulate disease progression in humans have not been systematically validated

Enzymatic activity was defined as the quantity of the enzyme required to catalyze the synthesis of 1 nM of the superoxide radical anion per minute

Different cell cycle phases present differential radiation sensitivity with late S-phase cell being the most radioresistant and late G2 and mitosis being the most sensitive [115]