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The release of inflammatory factors, such as cytokines and chemokines, by activated microglia can contribute to the perpetuation of neuroinflammation and exacerbate neuronal apoptosis (programmed cell death)

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P values indicated, calculated by two-way ANOVA with dks multiple comparisons test ( b, d )

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For example, a recent systematic review and meta-analysis by Tan et al

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A number of findings has indicated that AKT acts as a positive regulator of OPC differentiation to OLs, myelination, and myelin thickness 28,29,30 , as well as the upregulation of MBP gene expression in lithium chloride-treated mixed glial cells 31

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38 DjonlagicI.GuoM.MatteisP.CarusonaA.StickgoldR.MalhotraA

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