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FIGURE 4 Potential Role of Chronic Physical Exercise on Immune System Modulation: Implications on Vitiligo Development It has been well established that structured chronic PE has an anti-inflammatory effect ( + T cells to melanocytes and to start the process of destruction of these cells (Figure 1B)

These may include: gas bloating constipation diarrhea heartburn A healthy gut will have less difficulty processing food and eliminating waste, which may lead to fewer of these symptoms

By elevating oxidative stress, NRF2 degradation induces apoptosis in cancer cells and increases their sensitivity to chemotherapeutic agents, thereby enhancing the effectiveness of chemotherapy [95]

Moreover, what is known so far is that the abnormal immune response influence all stages of the disease, and potentially explains the elevated rates of comorbid inflammatory diseases found in these patients [128]

Crdenas-de la Cruz M, Salas-Pacheco J, Vzquez-Alaniz F, La Llave-Len O, Castellanos-Jurez F et al

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