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Simonds, W

Khan SR, Sharma B, Chawla PA, Bhatia R

10.7.3 Microglia: the metabolic checkpoint The decision of microglia to either support or prune neurons and synapses may be guided by a metabolic checkpoint. We postulate that microglia constantly assess the metabolic fitness of neighboring neurons by sensing specific metabolites released from dysfunctional cells

Violent suicidal behaviour in bipolar disorder is associated with nitric oxide synthase 3 gene polymorphism

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95,96 Although alcohol dehydrogenase can metabolize alcohol relatively safely to acetaldehyde that is converted to acetate by mitochondria, chronically high alcohol consumption results in a relative increase in alcohol metabolism by the cytochrome p450 enzyme CYP2E1, a pathway that generates ROS