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26 Within the TME, cancer cells can establish an immunosuppressive metabolic microenvironment by depriving immune cells of vital metabolites such as glucose and oxygen while also elevating the levels of mediators such as lactate and adenosine that limit the function of immune cells

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Hsp90, in particular, serves to stabilize client proteins, including calcineurin, important for tolerating azole, echinocandin, and polyene fungicidal activity

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