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Mondola et al

Transected rat Achilles tendons treated with the peptide showed not only faster healing but qualitatively better tissue organization

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High-resolution MS was performed using electrospray ionization and time-of-flight mass analysis

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Experimental conditions were optimized to maintain reaction linearity and to limit substrate conversion to 100-fold higher than cyclase activity ( + , a non-hydrolyzable NAD + analogue with enhanced GDPR-Cyclase activity