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Statements Data availability statement The original contributions presented in the study are included in the article/Supplementary material, further inquiries can be directed to the corresponding authors

Consistent with these findings, the pharmacological inhibition or downregulation of CD73 (which mediates the extracellular conversion of NMN to NR) largely abrogates the rescue effects of NMN in FK866-treated OVCAR-3 ovarian cancer cells, A549 lung cancer cells, and U87 glioblastoma cells by impairing the extracellular provision of NR from NMN [32,200]