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Of the intranasally challenged mice, 20% developed meningitis without bacteremia, and the authors found that the infection induced a decreased expression and a relocation of the junction protein N-cadherin in the olfactory epithelium, which connects the nasopharynx with the CNS

A.F.O., C.V., F.I.R., K.M.A., A.M.P., A.B.N., P.A.C., S.C.H., J.J.G., and C.C.H approved final version of the manuscript

Additionally, cotreatment with piperine reversed these changes, by enhancing the neurobehavioral performance, rebuilding the level of 5-HT, boosting MAO activity, and decreased neuronal degeneration in striatal tissue in experimental rats

10.1038/s41551-023-01093-3

doi:10.1017/S0029665100000847

Also deemed The Mother of Antioxidants, glutathione (GSH) is not only critical to preventing disease but to detoxification and overall healthy immune function.