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The UPR also suppresses translation of ER client proteins to decrease the overall protein load in the ER, induces autophagy to assist in protein degradation (Yorimitsu et al., 2006), and activates regulated mRNA degradation to diminish protein influx (Hollien et al., 2009)

Stroke 52 , 20962105 (2021)

F., Zengin, G., Xu, S., Nabavi, S