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Rigid spherical NPs are not efficiently cleared by renal filtration if their hydrodynamic diameter exceeds 5.5 nm [40]

Nucleic Acids Res 35:W429W432 Kang WH, Park YH, Park HM (2010) The LAMMER kinase homolog, Lkh1, regulates Tup transcriptional repressors through phosphorylation in Schizosaccharomyces pombe

The method according to any one of claims 59-76, wherein said antibody and/or immunoconjugate is administered in conjunction with another anti-cancer drug and/or a hormone

By contrast, the presence of the inhibitor forces the Tyr296 side chain to a closed conformation, hindering the NADPH attachment, and leading to enzyme inhibition