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It could not only upregulate antioxidant enzymes but also inhibit the oxidative stress-mediated activation of inflammatory factors (e.g., NF-B, TNF-, IL-1, and IL-6) (Zhang Q

12 , eaba0599 (2020)

Tocopherols, particularly d--Tocopherol (RRR--Tocopherol), characterized by their chromanol ring and phytyl tail, have long been recognized for their high bioavailability and established antioxidant properties, making them a cornerstone of vitamin E research (Kuchan et al., 2018, Traber and Atkinson, 2007)