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One study found that blood levels of cytokines, including IL-6 and TNF-, were significantly higher in depressed patients than in healthy controls (202), and that these pro-inflammatory cytokines, especially IL-6, IL-1, and TNF-, promote the production of Th17, which has been implicated in depression and other CNS disorders closely associated with them (203)

03 Burning or stinging at the injection site This usually means the solution is too cold (just out of the fridge) or was injected too quickly

One study conducted on rats found IGF-1 administration to increase excitatory synaptic transmission in CA1 by 40%

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