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10.1002/ange.201204018 63 XieF.WangM.ChenQ.ChiT.ZhuS.WeiP.et al (2022)

This task is made more complex by the magnitude of the biological system involvement or activation/deactivation

In a different investigation, Prathiba et al

Li X, Zhang Y, Wang Z

Involvement of the IL-1 system in experimental autoimmune encephalomyelitis and multiple sclerosis: breaking the vicious cycle between IL-1beta and GM-CSF

Variations at every methodological step, including sample collection, DNA extraction kits, sequencing platforms, and bioinformatic pipelines, can introduce substantial technical bias